It is now understood, for example, that great height is due to the combination of an unusually large number of positive variants, and possibly some very rare mutations that have a large effect on their own.
The genomics researcher George Church maintains a list of some of these single mutations. They include a variant of LRP5 that leads to extra-strong bones, a variant of MSTN that produces extra lean muscle, and a variant of SCN9A that is associated with pain insensitivity.4
Church has also been involved in one of the greatest scientific breakthroughs of recent decades: the development of a highly efficient gene editing tool called CRISPR, which has been approved for clinical trials for medical applications. If CRISPR-related technologies develop as anticipated, designer humans are at most a few decades away. Editing is most easily done soon after conception, when the embryo consists of only a small number of cells, but it is also possible in adults.
I don’t even know now what I want for my first post-singularity birthday ;D
Anyone else here fervently hoping for the (technological) singularity to arrive ASAP, BTW?